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$30/h
1st lesson free!
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Lessons offered by Mihai
  • Individual
  • In group
The lessons will be held
Taught subjects
  • Mathematics
  • Algebra
  • Trigonometry
  • Chemistry
  • Organic chemistry
  • Precalculus & Calculus
Levels
  • All Levels

Medicinal chemist with over 15 years of experience in math and science preparation.

Methodology

First I will try to understand the student's concerns and struggles, and figure out areas in need of improvement. Next, I will establish a dialogue with both the student and the parent(s) to establish the minimum goals we have to reach. I will then empower the student to master the subject matter and open new opportunities for her/him.

Background

Organic chemist with a passion for teaching math and science, primarily focused on college admission preparation. Will provide individually-tailored tutoring program to address the needs of individual student. Highly professional and transparent. My enthusiasm for math and science is infectious.

Rates

Rate for online lessons : $30/h
Rate for 5 hours of lessons : $25
Rate for 10 hours of lessons : $25
Lessons offered by Mihai
Individual
In group
The lessons will be held
at your home
Taught subjects
  • Mathematics
  • Algebra
  • Trigonometry
  • Chemistry
  • Organic chemistry
  • Precalculus & Calculus
Levels
  • All Levels

Mihai's resume

Mihai D. Azimioara

Teaching Experience

San Diego Math Circle
• Lecturer and teacher on mathematical logic, algebraic operators, number theory and point group theory (2012-2019) and introductory chemistry (2019).

Private tutor
• Tutored high school students in precalculus, AP calculus, statistics, AP chemistry and physics (2009-2020).

Harvard University:
• Department of Chemistry, July - November 1995: Designed and taught an informal course on “Advanced Tutorial on NMR Spectroscopy for Organic Chemists”;
• September 1989 - June 1990: Teaching assistant, sophomore- and junior-level organic chemistry lecture sessions (Chem 30), and laboratory (Chem 135).

California Institute of Technology:
• Department of Chemistry, April - June 1989: Teaching assistant, freshman- and sophomore-level organic chemistry laboratory (Chem 4b).

East Los Angeles Community College:
• Tutor in mathematics (precalculus, calculus), chemistry, and physics (1995 - 1996).

Academic Research Experience

Harvard University Cambridge, MA
Scientific staff July 1995 - March 1996
Graduate Research Assistant September 1989 – June 1995
• Developed chiral auxiliary groups for diastereoselective reactions using - stacking stabilizing interactions for optimum selectivity;
• Performed mechanistic studies using NMR and X-ray crystallography of various enantioselective reactions, such as: reductions of ketones using oxazaborolidine catalysts; dihydroxyosmylation reactions catalyzed by bidentate amines; Diels-Alder reactions using tryptophan-derived Lewis acid catalyst and prochiral precursors; also, performing conformational studies of various substrates and chelates in solution and solid states.

California Institute of Technology Pasadena, CA
Undergraduate Research Associate Summer 1989

Undergraduate research in the Department of Chemistry included: synthesis, purification and structural assignment of strained bicyclic and small-ring olefins for use in ring-opening metathesis polymerization (ROMP) reactions.

California Institute of Technology Pasadena, CA
Undergraduate Research Assistant 1987, Summer 1988

Undergraduate research in the Department of Chemistry included: synthesis of cationic tags for use in peptide sequencing using mass spectrometry; gas-phase isotope enrichment of 15NH3 in natural ammonia using selective IR-laser excitation.

Occidental College Eagle Rock, CA
Undergraduate Research Assistant Summer 1986

Undergraduate research included: isolation and purification of human erythrocyte glucose-6-phosphate dehydrogenase from expired human AB-type blood using affinity gel; performing binding studies of this enzyme using 14C-labeled substrates.

Career Summary

Plexium, Inc. San Diego, CA
Director of Chemistry April 2018 – May 2020
• Led the effort of discovering novel E3-ligase molecular glues and PROTACs for targeted protein degradation with applications in immuno-oncology.
• Played a major role in setting up and directing the medicinal chemistry group and in coordinating the collaboration with CROs. This also involved all the setting up and moving to a new laboratory.
• Contributed to the development of the DELPhe high-throughput discovery platform.

Genomics Institute of the Novartis Research Foundation (GNF) San Diego, CA
Investigator October 2003 – March 2018
• Collaborated on a variety of early-discovery research programs (hit ID, selection and validation; hit-to-lead generation; lead optimization and selection) in metabolic diseases, oncology, immunology and cystic fibrosis.
• Managed as a junior project lead the development of a series of GPR119 agonists for the treatment of type 2 diabetes and of two different series of CFTR correctors for the treatment of cystic fibrosis.
• As part of a multidisciplinary team, delivered over ten different lead series to preclinical development programs.
• Mentored a number of junior chemists in analytical and synthetic chemistry.
• Optimized key synthetic steps in high-priority projects in order to meet stringent deadlines for compound scale-up and SAR optimization.
• Collected, analyzed and curated necessary data for nominating outstanding leads for preclinical consideration.

Ambit Biosciences San Diego, CA
Research Scientist April 2002- June 2003
• Developed synthetic methods for biologically-active molecules used in linking to a poly-(ethylene glycol) biotinylated polymer with applications for testing in phage-display reverse-screening assays.
• Independently managed medicinal chemistry projects around a number of kinase-inhibitor leads generated from the phage-display platform.

Arena Pharmaceuticals, Inc. San Diego, CA
Research Scientist April 2000 – April 2002
• Managed three G-protein-coupled receptor projects.
• Trained and supervised three Research Associates in medicinal chemistry.

Tanabe Research Laboratories, USA, Inc. San Diego, CA
Research Associate November 1998 - March 2000
• Synthesized a number of small-molecule inhibitors of integrin assembly for anti-inflammatory treatments.

ARIAD Pharmaceuticals Cambridge, MA
Senior Associate Scientist November 1996 - October 1998
• Designed and synthesized a number of small-molecule, peptide and peptidomimetic selective inhibitors of the tyrosine kinase Src; these specific SH2-domain ligands were designed for the treatment of osteoporosis by inhibiting osteoclast activity.
• Developed HPLC methods for gram-scale separation of diastereomers.

Biogen, Inc. Cambridge, MA
Temporary Research Associate March - November 1996
• Synthesized a number of peptide derivatives for activity towards asthma treatment.
• Performed NMR conformational analysis on compounds of interest that led to a new series of compounds.


Education

Harvard University Cambridge, MA
Master of Arts, Organic Chemistry June 1992

California Institute of Technology Pasadena, CA
Bachelor of Science, with Honors in Chemistry June 1989

Publication List:

Patents

1. Azimioara, Mihai; Chen, Bei; Epple, Robert; Lajiness, James Paul; Mathison, Casey Jacob Nelson; Nabakka, Juliet; Nikulin, Victor Ivanovich; Patel, Sejal; Phillips, Dean Paul; Rucker, Paul Vincent; Valiere, Andrew; Wu, Baogen; Yan, Shanshan; Zhu, Xuefeng “N-(pyridin-2-yl)pyridine-sulfonamide Derivatives and their Use in the Treatment of Disease” WO 2020/161623 A1 2020.

2. Azimioara, Mihai; Bursulaya, Badry; Jiang, Songchun; Mathison, Casey Jacob Nelson; Nikulin, Victor Ivanovich; Nguyen, Truc Ngoc; Okram, Barun; Patel, Sejal; Phillips, Dean Paul; Whitehead, Lewis; Wu, Baogen; Yan, Shanshan; Zhu, Xuefeng “Macrocyclic Compounds and Their Use in the Treatment of Disease” WO 2020/128925 A1 2020.

3. Azimioara, Mihai; Chen, Bei; Epple, Robert; Hardy, Declan; Honda, Ayako; Lam, Philip; Malik, Hasnain Ahmed; Meier, Fabio; Nguyen, Truc Ngoc; Okram, Barun; Patel, Sejal; Rodriguez, Rodrigo; Shaw, Duncan; Shen, Yiping; Wu, Baogen “N-(Pyridin-2-ylsulfonyl)cyclopropanecarboxamide Derivatives and Their Use in the Treatment of a CFTR-mediated Disease” WO 2020/128768 A1 2020.

4. Azimioara, Mihai; Chen, Bei; Epple, Robert; Honda, Ayako; Lam, Philip; Malik, Hasnain Ahmed; Mathison, Casey Jacob Nelson; Nguyen, Truc Ngoc; Nikulin, Victor Ivanovich; Patel, Sejal; Phillips, Dean Paul; Rodriguez, Rodrigo A.; Wu, Baogen; Zhu, Xuefeng “N-(pyridin-2-yl)pyridine-sulfonamide Derivatives and their Use in the Treatment of Disease” US2(concealed information) 2020.

5. Phillips, Dean Paul; Azimioara, Mihai; Chen, Bei; Epple, Robert; Nikulin, Victor Ivanovich; Rodriguez, Rodrigo A.; Patel, Sejal; Honda, Ayako; Nguyen, Truc Ngoc; Lam, Philip; Wu, Baogen; Mathison, Casey Jacob Nelson; Malik, Hasnain Ahmed; Zhu, Xuefeng “N-(Pyridin-2-yl)pyridine-sulfonamide derivatives and their use in the treatment of disease” WO 2018/042316 A1 2018.

6. Epple, Robert; Azimioara, Mihai; Cow, Christopher; Russo, Ross; Nikulin, Victor; Lelais, Gerald “Compounds and methods for modulating G-protein-coupled receptors” US 8394841 B2 2013.

7. Azimioara, Mihai; Cow, Christopher; Epple, Robert; Lelais, Gerald; Mecom, John; Nikulin, Victor, “Preparation of 4-(pyridin-4-yl)phenyl azetidine compounds as modulators of GPR119 activity” WO 2011/044001 A1 2011.

8. Alper, Phillip; Azimioara, Mihai; Cow, Christopher; Epple, Robert; Lelais, Gerald; Mutnick, Daniel; Nikulin, Victor “Preparation of pyrazolopyrimidine compounds as modulators of GPR119 activity” WO 2011/014520 A2 2011.

9. Azimioara, Mihai; Cow, Christopher; Epple, Robert; Jiang, Songchun; Lelais, Gerald; Mutnick, Daniel; Wu, Baogen “Preparation of pyridopyrimidines and other nitrogen-containing heterocyclic compounds as therapeutic modulators of GPR119 activity” WO 2009/105717 A1 2009.

10. Alper, Phillip; Azimioara, Mihai; Cow, Christopher; Epple, Robert; Jiang, Songchun; Lelais, Gerald; Michellys, Pierre-Yves; Mutnick, Daniel; Nikulin, Victor; Westcott-Baker, Lucas “Compounds and compositions as modulators of GPR119 activity” WO 2009/038974A1, 2009.

11. Alper, Phillip; Azimioara, Mihai; Cow, Christopher; Epple, Robert; Jiang, Songchun; Lelais, Gerald; Michellys, Pierre-Yves; Nguyen, Truc Ngoc; Westcott-Baker, Lucas; Wu, Baogen “Compounds and compositions as modulators of GPR119 activity” WO 2008/097428A3, 2008.

12. Epple, Robert; Azimioara, Mihai; Cow, Christopher; Russo, Ross; Nikulin, Victor; Lelais, Gerald “Compounds and methods for modulating G-Protein-coupled receptors” WO 2008/121570A1, 2008.

13. Epple, Robert; Azimioara, Mihai; Cow, Christopher; Russo, Ross; Nikulin, Victor; Lelais, Gerald “Compounds and methods for modulating G-Protein-coupled receptors” WO 2008/103501A1, 2008.

14. Epple, Robert; Azimioara, Mihai; Cow, Christopher; Russo, Ross; Nikulin, Victor; Lelais, Gerald “Thiazole derivatives as modulators of G-Protein-coupled receptors” WO 2008/103500 A1, 2007.

15. Epple, Robert; Russo, Ross; Azimioara, Mihai “Compounds and compositions as PPAR modulators” WO 2007/089667 A1, 2007.

16. Epple, Robert; Russo, Ross; Azimioara, Mihai; Cow, Christopher; Molteni, Valentina; Li, Xiaolin; Chianelli, Donatella “Spiro-imidazole derivatives as PPAR modulators” WO 2007/087448 A1, 2007.

17. Epple, Robert; Cow, Christopher; Xie, Yongping; Wang, Xing; Russo, Ross; Azimioara, Mihai; Saez, Enrique “Compounds And Compositions As PPAR Modulators,” US(concealed information), 2006.

18. Epple, Robert; Cow, Christopher; Azimioara, Mihai; Russo, Ross; Xie, Yongping; Wang, Xing “Compounds and compositions as PPAR modulators” WO 2007/056366 A3, 2006.

19. Epple, Robert; Xie, Yongping; Wang, Xing; Russo, Ross; Cow, Christopher; Azimioara, Mihai “Compounds and compositions as PPAR modulators” WO 2007/056497 A1, 2006.

20. Epple, Robert; Cow, Christopher; Azimioara, Mihai; Russo, Ross “Oxazole and thiazole PPAR modulators” WO 2007/056496 A1, 2006.

21. Jones, Robert; Semple, Graeme; Fioravanti, Beatriz; Pereira, Guilherme; Calderon, Imelda; Uy, Jane; Duvvuri, Kameshwari; Choi, Jin; Xiong, Yifeng; Dave, Vibha; Azimioara, Mihai “1,2,3-Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia” US 0217379 A1 and EP 1927594 A1, 2006.

22. Epple, Robert; Cow, Christopher; Xie, Yongping; Wang, Xing; Russo, Ross; Azimioara, Mihai; Saez, Enrique “Compounds and Compositions as PPAR Modulators,” WO 2005/116000A1 and EP1748993 A1, 2005.

23. Epple, Robert; Russo, Ross; Azimioara, Mihai; Xie, Yongping “Compounds and Compositions as PPAR Modulators,” WO 2005/113519 A1 and EP 1756062 A1, 2005.

24. Epple, Robert; Azimioara, Mihai “Compounds and Compositions as PPAR Modulators,” WO 2005/113506 A1 and EP1745027 A1, 2005.


Journal Articles and Publications

1. Velcicky, Juraj; Mathison, Casey J. N.; Nikulin, Victor; Pflieger, Daniel; Epple, Robert; Azimioara, Mihai; Cow, Christopher; Michellys, Pierre-Yves; Rigollier, Pascal; Beisner, Daniel R.; et al. “Discovery of Orally Active Hydroxyethylamine-Based SPPL2a Inhibitors” ACS Medicinal Chemistry Letters 2019, 10(6), 887-892.

2. Azimioara, Mihai*; Alper, Phil; Cow, Christopher; Mutnick, Daniel; Nikulin, Victor; Lelais, Gerald; Mecom, John; McNeill, Matthew; Michellys, Pierre-Yves; Wang, Zhiliang; et al. “Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists” Bioorganic & Medicinal Chemistry Letters 2014, 24(23), 5478-5483.

3. Alper, Phil; Azimioara, Mihai; Cow, Christopher; Mutnick, Daniel; Nikulin, Victor; Michellys, Pierre-Yves; Wang, Zhiliang; Reding, Esther; Paliotti, Michael; Li, Jing; et al. “Discovery of structurally novel, potent and orally efficacious GPR119 agonists” Bioorganic & Medicinal Chemistry Letters 2014, 24(10), 2383-2387.

4. Epple, Robert; Cow, Christopher; Xie, Yongping; Azimioara, Mihai; Russo, Ross; Wang, Xing; Wityak, John; Karanewsky, Donald S.; Tuntland, Tove; Nguyen-Tran, Van T. B.; et al. “Novel Bisaryl Substituted Thiazoles and Oxazoles as Highly Potent and Selective Peroxisome Proliferator-Activated Receptor δ Agonists” Journal of Medicinal Chemistry 2010, 53(1), 77-105.

5. Robert Epple, Mihai Azimioara, Ross Russo, Yongping Xie, Xing Wang, Christopher Cow, John Wityak, Don Karanewsky, Badry Bursulaya, Andreas Kreusch, Tove Tuntland, Andrea Gerken, Maya Iskandar, Enrique Saez, H. Martin Seidel and Shin-Shay Tian “3,4,5-Trisubstituted Isoxazoles as Novel PPAR Agonists: Part 2” Bioorganic & Medicinal Chemistry Letters 2006, 16, 5488–5492.

6. Robert Epple, Ross Russo, Mihai Azimioara, Christopher Cow, Yongping Xie, Xing Wang, John Wityak, Don Karanewsky, Andrea Gerken, Maya Iskandar, Enrique Saez, H. Martin Seidel and Shin-Shay Tian “3,4,5-Trisubstituted isoxazoles as novel PPAR agonists: Part 1” Bioorganic & Medicinal Chemistry Letters 2006, 16, 4376-4380.

7. Robert Epple, Mihai Azimioara, Ross Russo, Badry Bursulaya, Shin-Shay Tian, Andrea Gerken, and Maya Iskandar “1,3,5-Trisubstituted Aryls as Highly Selective PPAR Agonists” Bioorganic & Medicinal Chemistry Letters 2006, 16, 2969-2973.

8. Miles A. Fabian, William H. Biggs III, Daniel K. Treiber, Corey E. Atteridge, Mihai D. Azimioara, Michael G. Benedetti, Todd A. Carter, Pietro Ciceri, Philip T. Edeen, Mark Floyd, Julia M. Ford, Margaret Galvin, Jay L. Gerlach, Robert M. Grotzfeld, Sanna Herrgard, Darren E. Insko, Michael A. Insko, Andiliy G. Lai, Jean-Michel Lélias, Shamal A. Mehta, Zdravko V. Milanov, Anne Marie Velasco, Lisa M. Wodicka, Hitesh K. Patel, Patrick P. Zarrinkar & David J. Lockhart “A Small Molecule−kinase Interaction Map for Clinical Kinase Iinhibitors” Nature Biotechnology 2005, 23, (3) 329-336.

9. Shakespeare, W. C.; Bohacek, R. S.; Azimioara, M. D.; Macek, K. J.; Luke, G. P.; Dalgarno, D. C.; Hatada, M. H.; Lu, X.; Violette, S. M.; Bartlett, C.; Sawyer, T. K. “Structure-Based Design of Novel Bicyclic Nonpeptide Inhibitors for the Src SH2 Domain” J. Med. Chem. 2000, 43, 3815-3819.

10. Shakespeare, W. C.; Yang, M.; Bohacek, R.; Cerasoli, F.; Stebbins, K.; Sundaramoorthi, R.; Azimioara, M.; Vu, C.; Pradeepan, S.; Metcalf, C.; Haraldson, C.; Merry, T.; Dalgarno, D.; Narula, S.; Hatada, M.; Lu, X.; van Schravendijk, M. R.; Adams, S.; Violette, S.; Smith, J.; Guan, W.; Bartlett, C.; Herson, J.; Iuliucci, J.; Weigele, M.; Sawyer, T. “Structure-based design of an osteoclast-selective, nonpeptide Src homology 2 inhibitor with in vivo antiresorptive activity” Proc. Natl. Acad. Sci. USA 2000, 97, 9373-9378.

11. Shakespeare, W. C.; Bohacek, R. S.; Narula, S. S.; Azimioara, M. D.; Yuan, R. W.; Dalgarno, D. C.; Madden, L.; Botfield, M. C.; Holt, D. A. “An Efficient Synthesis of a 4’-Phosphonodifluoromethyl-3’-formyl-phenylalanine Containing Src SH2 Ligand,” Bioorganic & Medicinal Chemistry Letters 1999, 9, 3109-3112.

12. Rickles, R. J.; Henry, P. A.; Guan, W.; Azimioara, M. D.; Shakespeare, W. C.; Violette, S.; Zoller, M. J. “A novel mechanism-based mammalian cell assay for the identification of SH2-domain-specific protein-protein inhibitors,” Chemistry & Biology 1998, 5, 529-538.

13. Corey, E. J.; Azimioara, M. D.; Fischer, A. K. “A Novel Synthesis of the Fluorene Skeleton,” Tetrahedron Letters 1997, 38, 6625 - 6626.

14. Corey, E. J.; Rohde, J. J.; Fischer, A.; Azimioara, M. D. “A Hypothesis for Conformational Restriction in Complexes of Formyl Compounds with Boron Lewis Acids. Experimental Evidence for Formyl CH--O and CH--F Hydrogen Bonds,” Tetrahedron Letters 1997, 38, 33 - 36.

15. Corey, E. J.; Sarshar, S.; Azimioara, M. D.; Newbold, R.; Noe, M. C. “X-Ray Crystal and NMR Structure of a Highly Reactive Bidentate 1,2-Diamine—OsO4 Complex, Formally a 20-Electron outer Valence Shell Species. Mechanistic Implications for the 1,2-Diamine-Accelerated Dihydroxylation of Olefins by OsO4,” J. Am. Chem. Soc. 1996, 118, 7851 - 7852.

16. Fieser & Fieser's “Reagents for Organic Synthesis,” vol. 17, 1994, Wiley-Interscience, New York, NY (coeditor).

17. Corey, E. J.; Azimioara, M.; Sarshar, S. “X-Ray Crystal Structure of a Chiral Oxazaborolidine Catalyst for Enantioselective Carbonyl Reduction,” Tetrahedron Letters 1992, 33, 3429 - 3430.

18. Corey, E. J.; Loh, T.-P.; Roper, T. D.; Azimioara, M. D.; Noe, M. C. “The Origin of Greater Than 200:1 Enantioselectivity in a Catalytic Diels-Alder Reaction As Revealed by Physical and Chemical Studies,” J. Am. Chem. Soc. 1992, 114, 8290 - 8292.

19. Corey, E. J.; Loh, T.-P.; Sarshar, S.; Azimioara, M. “The Structure of the 2-Methylacrolein Boron Trifluoride Complex in the Crystalline Phase and in Solution,” Tetrahedron Letters 1992, 33, 6945 - 6948.


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